If you're using wooden skewers, soak them in water for 10-30 minutes to prevent burning on the grill.
In a medium bowl, whisk together the melted butter, lemon juice, garlic powder, honey, and Cajun or Creole seasoning.
Add the thawed shrimp to the marinade and stir. Cover and let marinade at room temperature for 20 minutes. **If you are going to marinade longer than 20 minutes, please marinade in the refrigerator.
Thread the shrimp onto skewers. Grill each skewer for 2-3 minutes per side. Just until shrimp is cooked and no longer transparent.
NOTE: Prep-time includes marinating.
NOTE: I use easy peel shrimp that has already been deveined, and grill with the shell on. You can remove the shells before marinating if you wish.