Pizza Baked Spaghetti is the ultimate mashup of two family favorites! Spaghetti gets tossed in vodka sauce, then layered with seasoned ground beef, three different cheeses, and plenty of pepperoni.
Preheat the oven to 375 degrees Fahrenheit and lightly grease a 9x13-inch baking dish.
Cook the spaghetti in well-salted water until al dente, drain, and toss with the prepared vodka sauce until evenly coated.
While the spaghetti cooks, brown the ground beef in a large skillet over medium-high heat, breaking it into crumbles as it cooks.
Season the beef with garlic powder, onion powder, oregano, salt, pepper, and red pepper flakes, stir well, and cook for 1 minute before removing from the heat.
In a small bowl, combine the mozzarella, provolone, and parmesan.
Spread half of the spaghetti mixture into the prepared baking dish.
Sprinkle half of the cheese mixture evenly over the spaghetti.
Scatter half of the seasoned ground beef over the cheese.
Arrange half of the pepperoni slices over the beef.
Top with the remaining spaghetti mixture.
Sprinkle the remaining cheese mixture evenly over the spaghetti.
Scatter the remaining ground beef over the cheese.
Arrange the remaining pepperoni slices over the top in a single layer.
Bake uncovered for 25-30 minutes until the cheese is melted, the casserole is bubbling around the edges, and the pepperoni is lightly crisped.
Serve hot with extra Parmesan and chopped fresh parsley for garnish if desired.
Notes
Storing: This pizza baked spaghetti can be stored in an airtight container in the fridge for up to 4 days.